Tianeptine is an antidepressant that has proven its value in the treatment of depression, due to its antidepressant efficacy, its ability to alleviate anxiety symptoms of depression without sedation, and its excellent acceptability profile.

Tianeptine (Stablon, Coaxil, Tatinol), is structurally similar to the tricyclic antidepressants. Unlike the tricyclics, however, it enhances the reuptake of serotonin instead of blocking it. Tianeptine has strong antidepressant and anxiolytic properties with a relative lack of sedative, anticholinergic and cardiovascular adverse effects, making it particular suitable for use in elderly patients and in those following alcohol withdrawal as these patients are known to be more sensitive to the adverse effects of psychotropic drugs.
Currently, tianeptine is approved in a host of countries in Europe, Asia and Latin America.

Tianeptine shows efficacy against serious depressive episodes (major depression), comparable to amitriptyline, imipramine and fluoxetine, but with fewer side effects. It was even more effective than maprotiline in a group of patients with coexisting depression and anxiety. Tianeptine also displays significant anxiolytic properties and is useful in treating a spectrum of anxiety disorders including panic disorder, as evidenced by a study in which those administered 35% CO2 gas on paroxetine (Paxil) or tianeptine (Stablon) therapy showed equivalent panic-blocking effects. A 2005 study in Egypt demonstrated tianeptine to be effective in men with depression and erectile dysfunction. Tianeptine is also being studied in the treatment of ADD/ADHD.

Before taking any prescription medicine, it is important that you consult your doctor!