Midazolam, (marketed under brand names Versed, Hypnovel and Dormicum) is a drug which is a benzodiazepine derivative. It has powerful anxiolytic, amnestic, hypnotic, anticonvulsant, skeletal muscle relaxant and sedative properties. It is considered a fast-acting benzodiazepine, with a short elimination half-life.

Midazolam is an imidazo-benzodiazepine derivative. It bounds to benzodiazepine receptors in central nervous system and blocks the reflexes via medulla oblongata reticular formation. Its action is sedative, hypnotic, anti-convulsive and muscle-relaxant. From therapeutic point of view it is important that sedative and hypnotic onset of action is rapid and of relatively short duration.

Midazolam absorption from gastrointestinal tract is rapid and bioavailability is over 40% after peroral administration. More than 96% of the absorbed dose is bound to plasma proteins in circulation.

INDICATONS

- Short-term treatment of severe forms of insomnia (especially when difficulty of falling asleep is in question, regardless whether initial falling asleep or falling asleep after early awakening is in question)

- Pre-medication of patients prior to surgical and diagnostic procedures

DOSAGE AND ADMINISTRATION
Flormidal tablets are taken perorally, with some liquid.

In insomnia treatment, due to rapid onset of action, ? to 1 tablet should be taken before bedtime. It is recommended that duration of treatment be as short as possible (not exceeding 2 weeks). In elderly and debilitated individuals, as well as in patients with impaired renal function, the half of usual dosage of midazolam is recommended.

For pre-medication purposes 1 tablet should be administered 30-60 minutes prior to planned procedure.

Before taking any prescription medicine, it is important that you consult your doctor!