The combination of these four active ingredients enables achievement of synergistic analgesia via administration of relatively low doses of any ingredient.
The similarity in the pharmacokinetic profiles of each active ingredient enables achievement of analgesic effect within 15 minutes following oral administration. Reduced analgesic doses of the active ingredients included in this combination, having different adverse reaction profiles, provide neglectable incidence of adverse reactions events.

Therapeutic indications of Caffetin are mild to moderate pains such as headache, toothache, migraine, postoperative and posttraumatic pain, neuralgia, ishialgia, myalgia, arthralgia and dismenorrhoea.