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Description Active substance: Carbamazepine Packaging: blister sheet 10 x 400 mg tablets Shipped from: India
Carbamazepine is an anticonvulsant and mood stabilizing drug, used primarily in the treatment of epilepsy and bipolar disorder. It is also used to treat ADD, ADHD, schizophrenia and trigeminal neuralgia.
The mechanism of action of carbamazepine and its derivatives is relatively well understood. Voltage-gated sodium channels are the molecular pores that allow brain cells (neurons) to generate action potentials, the electrical events that allow neurons to communicate over long distances. After the sodium channels open, to start the action potential, they inactivate, essentially closing the channel. Carbamazepine stabilizes the inactivated state of sodium channels, meaning that fewer of these channels are available to open, making brain cells less excitable.
When Carbamazepine is used in the treatment of Bipolar disorder the mode of action is inhibition of Glycogen synthase kinase-3.
Carbamazepine is known to render many hormonal contraception products ineffective, due to its action as a cytochrome P450 enzyme inducer, which is the system that metabolizes many oral contraceptives. Carbamazepine causes more cytochrome P450 enzyme to be produced, which hastens removal of the contraceptive from the blood plasma although the clinical significance of this effect is debatable.
Common side effects include drowsiness, motor coordination impairment and/or upset stomach. Carbamazepine preparations may also greatly decrease a person's alcohol tolerance.
Before taking any prescription medicine, it is important that you consult your doctor!
