Bupropion (amfebutamone) (brand names Wellbutrin and Zyban) is an antidepressant of the aminoketone class, chemically unrelated to tricyclics or selective serotonin reuptake inhibitors (SSRIs). It is similar in structure to the stimulant cathinone, and to phenethylamines in general. Bupropion is both a dopamine reuptake inhibitor and a norepinephrine reuptake inhibitor.

Bupropion is a selective catecholamine (norepinephrine and dopamine) reuptake inhibitor. It has only a small effect on serotonin reuptake. It does not inhibit MAO. The antidepressant effect of bupropion is considered to be mediated by its dopaminergic and noradrenergic action.

Indications
- The management of depression including Seasonal Affective Disorder, Major Depressive Disorder and others.
- Adjunctive in tobacco withdrawal
- Attention-deficit hyperactivity disorder
- Restless leg Syndrome

An advantage of bupropion over most conventional antidepressants is that it causes no sexual dysfunction in men and may even increase libido in both sexes. According to a recent study, bupropion does also increase libido in women with "hypoactive sexual desire disorder" but without signs of depression. Recent studies also suggest that Bupropion might increase sexual functioning in minority women who suffer from depression. It is too early to recommend treatment to these women, and further controlled studies are necessary to establish conclusive evidence.

Adults, 100 to 150 mg once daily. In patients unresponsive to a dose of 150 mg/day, the dose may be increased, at intervals of at least 1 week, to a maximum of 300 mg/day. Doses > 150mg/day should be given twice daily, preferably with at least 8 hours between successive doses. Severe hepatic impairment: If bupropion's use is deemed necessary, initiate therapy at a reduced dose, to a maximum dose of 100 mg every day or 150 mg every other day.

Before taking any prescription medicine, it is important that you consult your doctor!