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Description Brand name: Riclofen Active substance: Baclofen Packaging: blister sheet 10 x 10mg tablets Shipped from: India
Baclofen is an oral medication that relaxes skeletal muscles, the muscles that move the skeleton (also called striated muscle). Chemically, baclofen is related to gamma-aminobutyric acid (GABA), a naturally-occurring neurotransmitter in the brain. Neurotransmitters are chemicals that nerves use to communicate with one another. GABA released by some nerves causes the activity of other nerves to decrease. It is believed that baclofen, acting like GABA, blocks the activity of nerves within the part of the brain that controls the contraction and relaxation of skeletal muscle. Baclofen was approved by the FDA in November, 1977.
It is used for the treatment of spastic movement, especially in instances of spinal cord injury, spastic diplegia, multiple sclerosis and amyotrophic lateral sclerosis (Lou Gherig's Disease). Its beneficial effects result from actions at spinal and supraspinal sites. Baclofen can also be used to treat hiccups.
The usual starting dose of baclofen for adults is 5 mg given three
times daily. Based on the response, the dose can be increased gradually
every three days to a maximum of 80 mg/day in several doses.
The drug is rapidly absorbed after oral administration and is widely
distributed throughout the body. Biotransformation is low and the drug
is predominantly excreted in the unchanged form by the kidneys.
Symptoms of baclofen underdose (via intrathecal delivery) include
itching, hypotension, paresthesias, fever, and altered mental state
(including delusions and hallucinations).
Before taking any prescription medicine, it is important that you consult your doctor!
