Avandia, in addition to diet and exercise, improves blood sugar control in adults with type 2 (non-insulin-dependent) diabetes. Avandia can be used alone or in combination with a sulfonylurea or metformin, when diet, exercise, and one of these agents or diet, exercise, plus Avandia alone are not enough to control blood sugar.

Rosiglitazone is an anti-diabetic drug from the thiazolidinedione class. Like other thiazolidinediones, its mechanism of action is by activation of the intracellular receptor class of the peroxisome proliferator-activated receptors (PPARs), specifically PPAR. Rosiglitazone is a pure ligand of PPAR, and has no PPAR-binding action. Apart from its effect on insulin resistance, it appears to have an anti-inflammatory effect: nuclear factor kappa-B (NFB) levels fall and inhibitor (IB) levels increase in patients on rosiglitazone.

Do not use Avandia for type I diabetes (juvenile diabetes) or diabetic ketoacidosis.
If you have heart failure, fluid retention or active liver disease your health care provider will evaluate you to decide if Avandia is right for you.

Before taking any prescription medicine, it is important that you consult your doctor!