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Polycap is a five-in-one polypill created by Cadila Pharmaceuticals Limited of Ahmedabad, India that combines moderate levels of five different medications in a single, one-a-day pill aimed at reducing heart attacks and strokes. A 2009 study found that the combination of three blood pressure medications, a cholesterol reducer and aspirin cut the risks of heart attack and stroke in half, with no increase in adverse effects compared to taking the components separately.
While researchers have sought to create many different "polypills", combinations of active ingredients to treat various diseases, a pill targeted at heart attack and stroke risk was long-sought. While the benefits of reducing the number of pills patients would have to take seemed clear, concerns were raised that the shotgun approach would fit few patients, offering many too little of the medication they needed or components that they didn't need at all, while exposing them to side effects of all the medications included.
A hypothesis proposed by Wald and Law published in 2003 recommended a six-drug combination to be taken by patients over age 55 with cardiovascular disease events, that would include three half-dose antihypertensives drugs, aspirin, and statin. As tested, Polycap combines 100 milligrams of aspirin, with simvastatin (a generic version of Zocor, the cholesterol-lowering statin) and low doses of three blood pressure medications, atenolol, ramipril and thiazide.
A study called The Indian Polycap Study (TIPS) was sponsored by Cadila Pharmaceuticals Limited and led by Dr. Salim Yusuf of McMaster University in Hamilton, Ontario, and Dr. Prem Pais of St. John's Medical College in Bangalore, India. The results of the randomized, controlled, double-blind study, reported in March 2009 at a American College of Cardiology conference and published online by The Lancet, documented the outcome of 2,000 individuals with an average age of 54 given the medication, all of whom had at least one heart disease risk factor: diabetes, hypercholesterolemia, hypertension, obesity or smoking. The study was registered with ClinicalTrials.gov, number NCT00443794.
During a 12-week treatment period, 400 of the study participants were given Polycap. The remainder were divided into eight groups of 200 who were given either individual components or groups of them.[1] Three of the groups of 200 received only aspirin, simvastatin or thiazide respectively; Three groups received two of the three blood pressure medications; Another received all three blood pressure medications, while the last received all three combined with aspirin.
The individuals who were given Polycap saw their blood pressure drop from six to seven points for both their systolic and diastolic levels. These reductions in blood pressure could cut the risk of heart disease by 62% and of stroke by 48% based on the results of other studies that showed risk reductions from cutting blood pressure levels. The combined pill was almost as effective as the individual pills with no increase in side effects.
Before taking any prescription medicine, it is important that you consult your doctor!
